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Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue

Fecha de publicación: Fecha Ahead of Print:

Autores de CIPF

Participantes ajenos a CIPF

  • Guenantin, AC
  • Bahri, M
  • Rodriguez-Fdez, S
  • Honig, F
  • Kamzolas, I
  • Samuelson, I
  • Long, K
  • Awad, S
  • Bassett, A
  • Mendjan, S
  • Vallier, L
  • Rosen, BS
  • Chiarugi, D

Grupos de Investigación

Abstract

Increasing brown adipose tissue (BAT) mass and activation is a therapeutic strategy to treat obesity and complications. Obese and diabetic patients possess low amounts of BAT, so an efficient way to expand their mass is necessary. There is limited knowledge about how human BAT develops, differentiates, and is optimally activated. Accessing human BAT is challenging, given its low volume and anatomical dispersion. These constraints make detailed BAT-related developmental and functional mechanistic studies in humans virtually impossible. We have developed and characterized functionally and molecularly a new chemically defined protocol for the differentiation of human pluripotent stem cells (hPSCs) into brown adipocytes (BAs) that overcomes current limitations. This protocol recapitulates step by step the physiological developmental path of human BAT. The BAs obtained express BA and thermogenic markers, are insulin sensitive, and responsive to b-adrenergic stimuli. This new protocol is scalable, enabling the study of human BAs at early stages of development.

Datos de la publicación

ISSN/ISSNe:
2213-6711, 2213-6711

Stem Cell Reports  CELL PRESS

Tipo:
Article
Páginas:
641-655
PubMed:
33606988

Citas Recibidas en Web of Science: 12

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Keywords

  • BAT progenitors, brown adipose tissue, development, differentiation, human pluripotent stem cells, thermogenesis

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