Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.

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Autores de CIPF

Participantes ajenos a CIPF

  • Córdoba-Jover B
  • Ribera J
  • Portolés I
  • Lecue E
  • Pérez-Sisqués L
  • Mannara F
  • Solsona-Vilarrasa E
  • García-Ruiz C
  • Fernández-Checa JC
  • Casals G
  • Rodríguez-Revenga L
  • Álvarez-Mora MI
  • Arteche-López A
  • Díaz de Bustamante A
  • Calvo R
  • Pujol A
  • Azkargorta M
  • Elortza F
  • Malagelada C
  • Pinyol R
  • Huguet-Pradell J
  • Melgar-Lesmes P
  • Jiménez W
  • Morales-Ruiz M

Grupos de Investigación

Abstract

Transcription co-activator factor 20 (TCF20) is a regulator of transcription factors involved in extracellular matrix remodelling. In addition, TCF20 genomic variants in humans have been associated with impaired intellectual disability. Therefore, we hypothesized that TCF20 has several functions beyond those described in neurogenesis, including the regulation of fibrogenesis.

Datos de la publicación

ISSN/ISSNe:
1478-3223, 1478-3231

LIVER INTERNATIONAL  WILEY-BLACKWELL

Tipo:
Article
Páginas:
1822-1836
PubMed:
37312667

Citas Recibidas en Web of Science: 4

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Keywords

  • TCF20, collagen, liver fibrosis, metabolic disease, newborn lethality, succinate

Campos de Estudio

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