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  3. Towards the design of Personalised Polymer-based Combiantion Nanomedicines for Advanced Stage Breast Cancer Patients

Towards the design of Personalised Polymer-based Combiantion Nanomedicines for Advanced Stage Breast Cancer Patients

Datos básicos

Código Financiador:
Año inicial:
2015
Año final:
2020
PROY. INVEST. EUROPEA F.COMPETITIVA FIN. PUBLICA 1.724.168,97 €

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Participantes

Grupos de Investigación

Financiadores

COMMISSION OF EUROPEAN COMMUNITIES

Resultados del Proyecto

PEGylated proteins: A rational design for mitigating clearance mechanisms and altering biodistribution

Bossard, MJ, Vicent, MJ

Article. 10.1016/B978-0-444-64081-9.00002-4. 2020


A POLYMER CONJUGATE NANOMEDICINE INHIBITS LPS-INDUCED MAPK ACTIVATION AND REDUCES ENDOTOXEMIA-MEDIATED KIDNEY INFLAMMATION

Gonzalez-Guerrero, C; (...); Ramos, A

Meeting Abstract. 2017


Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Arroyo-Crespo, JJ; (...); Vicent, MJ

Article. 10.1002/adfm.201800931. 2018

  • Open Access.

Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1002/adma.201702888. 2017

  • Open Access.

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

Requejo-Aguilar, R; (...); Moreno-Manzano, V

Article. 10.1016/j.biomaterials.2016.10.032. 2017


Covalently captured dynamic self-assembled star-shaped polyglutamates as drug delivery vehicles

Duro-Castano, A; (...); Vicent, M

Meeting Abstract. 2017


Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression

Arroyo-Crespo JJ; (...); Vicent MJ

Article. 10.1002/ijc.32270. 2019


Design of personalised polymer based combination therapeutics for advanced stage breast cancer patients

Arminan, A; (...); Vicent, MJ

Meeting Abstract. 10.1158/1538-7445.AM2018-3726. 2018


Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery

Nino-Pariente, A; (...); Vicent, MJ

Article. 10.1002/mabi.201700029. 2017

  • Open Access.

Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery (vol 10, 1700029, 2017)

Nino-Pariente, A; (...); Vicent, MJ

Correction. 10.1002/mabi.201700245. 2017

  • Open Access.

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

Cordoba-David, G; (...); Ramos, AM

Article. 10.1038/s41598-020-58974-9. 2020


Envisioning the future of polymer therapeutics for brain disorders

Rodriguez-Otormin, F; (...); Vicent, MJ

Review. 10.1002/wnan.1532. 2019


EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P; (...); Gribbon, P

Article. 10.1177/2472555218816276. 2019


Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

Moura, LIF; (...); Florindo, HF

Review. 10.1039/c9mh00628a. 2019


Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats

Cheah, HY; (...); Japundzic-Zigon, N

Article. 10.1080/17435390.2017.1285071. 2017


HIF-1 alpha inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics

Arminan, A; (...); Duarte, IF

Article. 10.1080/1061186X.2017.1358728. 2017


High- throughput screening using a Drosophila model of Parkinson's disease

Lopez, FJ; (...); Paricio, N

Meeting Abstract. 2019


In Vivo Imaging of MMP-13 Activity Using a Specific Polymer-FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy

Duro-Castano, A; (...); Nagase, H

Article. 10.1002/adfm.201802738. 2018


Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study

Eldar-Boock, A; (...); Satchi-Fainaro, R

Article. 10.1080/1061186X.2017.1358727. 2017


Metabolomics facilitates the discrimination of the specific and-cancer effects of free and polymer conjugated doxorubicin in breast cancer models

Arminan, A; (...); Pineda-Lucena, A

Article. 10.1016/j.biomaterials.2018.02.015. 2018


Modulating angiogenesis with integrin-targeted nanomedicines

Duro-Castano, A; (...); Vicent, MJ

Review. 10.1016/j.addr.2017.05.008. 2017


Molecular platforms for targeted drug delivery

Maso K; (...); Pasut G

Review. 10.1016/bs.ircmb.2019.03.001. 2019


Nanomedicine for the Treatment of Advanced Prostate Cancer

Vicente-Ruiz, S; (...); Vicent, MJ

Review. 10.1002/adtp.202000136. 2021


Near-Infrared Activatable Phthalocyanine Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy

Cheah, HY; (...); Kiew, LV

Article. 10.1021/acs.molpharmaceut.8b00132. 2018


Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light-dark toxicity ratio toward an effective photodynamic cancer therapy

Kiew, LV; (...); Chung, LY

Article. 10.1016/j.nano.2017.02.002. 2017


PA-Curcumin Conjugate and Combined Therapy with Ependymal/Progenitor Cells Enhance Recovery from Spinal Cord Injury

Requejo, R; (...); Moreno, V

Meeting Abstract. 2016


pH-Responsive Polyacetal-Protein Conjugates Designed for Polymer Masked-Unmasked Protein Therapy (PUMPT)

Escalona, GR, Sanchis, J, Vicent, MJ

Article. 10.1002/mabi.201700302. 2018


Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer

Plyduang, T; (...); Vicent, MJ

Article. 10.1002/marc.201800265. 2018


Polymer therapeutics and stem cell therapies as a combinatorial approach for the treatment of chronic spinal cord injuries

Nebot, V; (...); Vicent, M

Meeting Abstract. 2017


Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Atkinson SP, Andreu Z, Vicent MJ

Review. 10.3390/jpm8010006. 2018


Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders.

Conejos-Sánchez I; (...); Vicent MJ

Article. 10.1039/c9nr06187h. 2020

  • Open Access.

Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges

Zagorodko, O; (...); Vicent, MJ

Review. 10.1002/mabi.201600316. 2017


Polypeptide-based conjugates as versatile therapeutics as single agents or in combination therapy

Zagorodko, O; (...); Vicent, M

Meeting Abstract. 2019


Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

Dolz-Pérez I; (...); Vicent MJ

Article. 10.1016/j.jconrel.2019.12.016. 2020


Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry

Cheah, HY; (...); Chung, LY

Review. 10.1002/jat.3437. 2017


Professor Ruth Duncan: a pioneer in the field of polymer therapeutics.

Satchi-Fainaro, R, Vicent, MJ, Richardson, S

Editorial Material. 10.1080/1061186X.2017.1371722. 2017


Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers

Nino-Pariente, A, Nebot, VJ, Vicent, MJ

Article. 10.2174/1381612822666151216152143. 2016


Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide

Lepland, A; (...); Scodeller, P

Article. 10.1021/acs.molpharmaceut.0c00226. 2020


The generation of stabilized supramolecular nanorods from star-shaped polyglutamates

Zagorodko, O, Nebot, VJ, Vicent, MJ

Article. 10.1039/c9py01442j. 2020

  • Open Access.

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation.

Melnyk T; (...); Vicent MJ

Article. 10.1016/j.addr.2020.10.007. 2020


Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells

Gallon, E; (...); Salmaso, S

Article. 10.1021/acs.biomac.5b00286. 2015


Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Arroyo-Crespo JJ; (...); Vicent MJ

Article. 10.1016/j.biomaterials.2018.09.023. 2018


Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine: glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I

Roncador, A; (...); Cellini, B

Article. 10.1016/j.nano.2016.12.011. 2017


Versatile star-shaped polypeptide conjugates with controlled self-assembly as therapeutics

Vicent, M

Meeting Abstract. 2017


Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1021/acs.molpharmaceut.5b00358. 2015


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