Portal de investigación
Bases moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas
Datos básicos
- Código Financiador:
- Año inicial:
- 2015
- Año final:
- 2018
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- No hay documentos
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Grupos de Investigación
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Resultados del Proyecto
A rare and revealing glimpse of the cerebrospinal fluid of patients with hepatic encephalopathy
Felipo, V, Montagnese, S
Article. 10.1016/j.jhep.2016.07.046. 2016
Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits
Urios, A; (...); Montoliu, C
Article. 10.1111/liv.13345. 2017
BLOCKING NMDA RECEPTORS PROLONGS SURVIVAL IN RATS WITH ACUTE LIVER FAILURE BY DUAL PROTECTIVE MECHANISMS IN KIDNEY AND BRAIN
Cauli, O; (...); Felipo, V
Meeting Abstract. 10.1016/S0168-8278(15)30290-7. 2015
Current state of knowledge of hepatic encephalopathy (part II): changes in brain white matter tracts integrity are associated with cognitive deficits in minimal hepatic encephalopathy
Montoliu, C, Felipo, V
Article. 10.1007/s11011-016-9909-8. 2016
Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor
Seifertova, M; (...); Kocan, A
Article. 10.1007/s00216-017-0533-1. 2017
Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway
Cabrera-Pastor, A; (...); Felipo, V
Article. 10.1038/srep33124. 2016
Extracellular CGMP normalizes TNF-alpha and membrane expression of AMPA receptors and spatial reference memory in hyperammonemic rats
Cabrera-Pastor, A; (...); Felipo, V
Meeting Abstract. 2017
Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved
Cabrera-Pastor, A; (...); Felipo, V
Article. 10.1038/s41598-017-18024-3. 2017
Extracellular Protein Kinase A Modulates Intracellular Calcium/Calmodulin-Dependent Protein Kinase II, Nitric Oxide Synthase, and the Glutamate-Nitric Oxide-cGMP Pathway in Cerebellum. Differential Effects in Hyperammonemia
Cabrera-Pastor, A, Llansola, M, Felipo, V
Article. 10.1021/acschemneuro.6b00263. 2016
Gender Differences in Spatial Learning, Synaptic Activity, and Long-Term Potentiation in the Hippocampus in Rats: Molecular Mechanisms
Monfort, P; (...); Felipo, V
Article. 10.1021/acschemneuro.5b00096. 2015
GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy
Johansson, M; (...); Felipo, V
Article. 10.1152/ajpgi.00073.2015. 2015
Hyperammonemia alters glycinergic neurotransmission and modulation of the glutamate-nitric oxide-cGMP pathway by extracellular glycine in cerebellum in vivo
Cabrera-Pastor, A, Taoro-Gonzalez, L, Felipo, V
Article. 10.1111/jnc.13579. 2016
Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane
Hernandez-Rabaza, V; (...); Felipo, V
Article. 10.1186/s12974-016-0505-y. 2016
In vivo administration of extracellular cGMP normalizes TNF-alpha and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1 beta, NMDA receptors in membrane and working memory in hyperammonemic rats
Cabrera-Pastor, A; (...); Felipo, V
Article. 10.1016/j.bbi.2016.05.011. 2016
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy
Dadsetan, S; (...); Felipo, V
Article. 10.1186/s12974-016-0710-8. 2016
Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy
Llansola, M; (...); Felipo, V
Article. 10.1016/j.neuint.2014.10.011. 2015
Is Cognitive Impairment in Cirrhotic Patients Due to Increased Peroxynitrite and Oxidative Stress?
Gimenez-Garzo, C; (...); Felipo, V
Article. 10.1089/ars.2014.6240. 2015
Minimal hepatic encephalopathy is associated with expansion and activation of CD4+ CD28(-), Th22 and Tfh and B lymphocytes
Mangas-Losada, A; (...); Felipo, V
Article. 10.1038/s41598-017-05938-1. 2017
Minimal hepatic encephalopathy is associated with increased capacity to eliminate superoxide and peroxynitrite in lymphocytes
Mangas-Losada, A; (...); Montoliu, C
Meeting Abstract. 10.1016/S0168-8278(17)30555-X. 2017
Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy
Agusti, A; (...); Felipo, V
Article. 10.1016/j.jsbmb.2015.08.020. 2016
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
Hernandez-Rabaza, V; (...); Felipo, V
Article. 10.1186/s12974-016-0549-z. 2016
NON INVASIVE BLOOD FLOW MEASUREMENT BY "ARTERIAL SPIN LABELING" DETECTS MINIMAL HEPATIC ENCEPHALOPATHY
Urios, A; (...); Montoliu, C
Article. 10.1016/S0168-8278(15)30378-0. 2015
Peripheral treatment with Infliximab prevents glial activation and neuroinflammation and restores cognitive and motor alterations in rats with chronic liver failure
Balzano, T; (...); Felipo, V
Meeting Abstract. 2017
Rats with Mild Bile Duct Ligation Show Hepatic Encephalopathy with Cognitive and Motor Impairment in the Absence of Cirrhosis: Effects of Alcohol Ingestion
Gimenez-Garzo, C; (...); Felipo, V
Article. 10.1007/s11064-014-1330-2. 2015
Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations
Felipo, V; (...); Llansola, M
Article. 10.3109/07420528.2015.1057640. 2015
Real-time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no-wash, no-lyse kinetic method
Balaguer, S; (...); Montoliu, C
Article. 10.1002/cyto.b.21237. 2017
Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy
Garcia-Garcia, R; (...); Montoliu, C
Article. 10.1371/journal.pone.0186463. 2017
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy
Dadsetan, S; (...); Felipo, V
Article. 10.3389/fnmol.2016.00106. 2016
Restoring the function of the glutamate-nitric oxide –cGMP pathway by treatments acting on different brain targets restores cognitive function in rats with minimal hepatic encephalopathy
Felipo, Vicente; (...); Gomez-Gimenez, Belen
Article. 10.1016/j.nhtm.2014.11.030. 2015
Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia
Cabrera-Pastor, A; (...); Felipo, V
Article. 10.1021/acschemneuro.5b00212. 2015
Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus
Gomez-Gimenez, B; (...); Felipo, V
Article. 10.1016/j.fct.2016.11.028. 2017
SILDENAFIL REDUCES NEUROINFLAMMATION AND RESTORES SPATIAL LEARNING IN RATS WITH HEPATIC ENCEPHALOPATHY. UNDERLYING MECHANISMS
Hernandez-Rabaza, V; (...); Felipo, V
Meeting Abstract. 10.1016/S0168-8278(16)00755-8. 2016
Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms
Hernandez-Rabaza, V; (...); Felipo, V
Article. 10.1186/s12974-015-0420-7. 2015
Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy
Agusti, A; (...); Felipo, V
Article. 10.1111/cns.12688. 2017
Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts
Belghiti, M; (...); Felipo, V
Article. 10.1007/s11064-016-1980-3. 2017
The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients
Tenorio-Laranga, J; (...); Felipo, V
Article. 10.1186/s12974-015-0404-7. 2015
The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients
Gimenez-Garzo, C; (...); Montoliu, C
Article. 10.1371/journal.pone.0171211. 2017
Translational research in hepatic encephalopathy: New diagnostic possibilities and new therapeutic approaches
Llansola, M; (...); Felipo, V
Article. 10.1016/j.nhtm.2014.11.057. 2015
Treatment with anti-TNFa reduces neuroinflammation and restores neurotransmission, learning and motor coordination in rats with hepatic encephalopathy
Dadsetan, S; (...); Felipo, V
Meeting Abstract. 10.1016/S0168-8278(17)31589-1. 2017
Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging (vol 37, pg 643, 2011)
Pellicer, B; (...); Pellicer, A
Correction. 10.1002/uog.15865. 2016