1. Inicio
  2. Publicaciones
  3. Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy

Fecha de publicación:

Autores de CIPF

  • Carmina Montoliu Felix

    Autor

  • Ana Agustí Feliu

    Autor

  • Vicente Hernandez Rabaza

    Autor

  • Andrea Cabrera Pastor

    Autor

  • Belen Gomez Giménez

    Autor

  • Michele Malaguarnera

    Autor

  • Sherry Dadsetan

    Autor

  • Raquel García García

    Autor

  • Tiziano Balzano

    Autor

  • Lucas Taoro González

    Autor

Participantes ajenos a CIPF

  • Belghiti, M

Grupos de Investigación

Abstract

The cognitive and motor alterations in hepatic encephalopathy (HE) are the final result of altered neurotransmission and communication between neurons in neuronal networks and circuits. Different neurotransmitter systems cooperate to modulate cognitive and motor function, with a main role for glutamatergic and GABAergic neurotransmission in different brain areas and neuronal circuits. There is an interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in HE. This interplay may occur: (a) in different brain areas involved in specific neuronal circuits; (b) in the same brain area through cross-modulation of glutamatergic and GABAergic neurotransmission. We will summarize some examples of the (1) interplay between glutamatergic and GABAergic neurotransmission alterations in different areas in the basal ganglia-thalamus-cortex circuit in the motor alterations in minimal hepatic encephalopathy (MHE); (2) interplay between glutamatergic and GABAergic neurotransmission alterations in cerebellum in the impairment of cognitive function in MHE through altered function of the glutamate-nitric oxide-cGMP pathway. We will also comment the therapeutic implications of the above studies and the utility of modulators of glutamate and GABA receptors to restore cognitive and motor function in rats with hyperammonemia and hepatic encephalopathy. (C) 2014 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0197-0186, 1872-9754

NEUROCHEMISTRY INTERNATIONAL  PERGAMON-ELSEVIER SCIENCE LTD

Tipo:
Article
Páginas:
15-19
PubMed:
25447766

Citas Recibidas en Web of Science: 43

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Hepatic encephalopathy; Minimal hepatic encephalopathy; Hyperammonemia; Glutamatergic neurotransmission; GABAergic neurotransmission; Cognitive function

Campos de Estudio

Proyectos asociados

Bases moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas

Investigador Principal: VICENTE FELIPO ORTS

MINISTERIO DE ECON. Y COMPET. . 2015

Identificación de un panel de metabolitos en sangre útil par

Investigador Principal: VICENTE FELIPO ORTS

CONSELLERIA DE SANIDAD . 2015

Compartir