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mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Fecha de publicación:

Autores de CIPF

Participantes ajenos a CIPF

  • Zabala-Letona, A
  • Arruabarrena-Aristorena, A
  • Martin-Martin, N
  • Fernandez-Ruiz, S
  • Sutherland, JD
  • Clasquin, M
  • Tomas-Cortazar, J
  • Jimenez, J
  • Torres, I
  • Quang, P
  • Ximenez-Embun, P
  • Bago, R
  • Galde-Olano, AU
  • Oizaga-Iriarte, AL
  • Acasa-Viscasillas, IL
  • Nda, MU
  • Torrano, V
  • Cabrera, D
  • van Liempd, SM
  • Cendon, Y
  • Castro, E
  • Murray, S
  • Revandkar, A
  • Alimonti, A
  • Zhang, YN
  • Barnett, A
  • Lein, G
  • Pirman, D
  • Cortazar, AR
  • Arreal, L
  • Prudkin, L
  • Astobiza, I
  • Valcarcel-Jimenez, L
  • Zuniga-Garcia, P
  • Fernandez-Dominguez, I
  • Piva, M
  • Caro-Maldonado, A
  • Sanchez-Mosquera, P
  • Castillo-Martin, M
  • Serra, V
  • Beraza, N
  • Gentilella, A
  • Thomas, G
  • Azkargorta, M
  • Elortza, F
  • Olmos, D
  • Efeyan, A
  • Anguita, J
  • Munoz, J
  • Falcon-Perez, JM
  • Barrio, R
  • Macarulla, T
  • Mato, JM
  • Martinez-Chantar, ML
  • Cordon-Cardo, C
  • Aransay, AM
  • Marks, K
  • Baselga, J
  • Tabernero, J
  • Nuciforo, P
  • Manning, BD
  • Marjon, K
  • Carracedo, A

Grupos de Investigación

Abstract

Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation(1,2). Here we show that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. By using integrative metabolomics in a mouse model(3) and human biopsies(4) of prostate cancer, we identify alterations in tumours affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis. Mechanistically, this metabolic rewiring stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability. This novel molecular regulation is validated in mouse and human cancer specimens. AMD1 is upregulated in human prostate cancer with activated mTORC1. Conversely, samples from a clinical trial with the mTORC1 inhibitor everolimus(5) exhibit a predominant decrease in AMD1 immunoreactivity that is associated with a decrease in proliferation, in line with the requirement of dcSAM production for oncogenicity. These findings provide fundamental information about the complex regulatory landscape controlled by mTORC1 to integrate and translate growth signals into an oncogenic metabolic program.

Datos de la publicación

ISSN/ISSNe:
0028-0836, 1476-4687

NATURE  NATURE PUBLISHING GROUP

Tipo:
Article
Páginas:
109-113
PubMed:
28658205

Citas Recibidas en Web of Science: 157

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Proyectos asociados

Caracterización molecular de células propagadoras de cáncer de pulmón como herramienta predictiva y para el diseño de terapias personalizadas

Investigador Principal: ROSA M FARRÀS RIVERA

INSTITUTO DE SALUD CARLOS III . 2016

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