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Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography.

Fecha de publicación:

Autores de CIPF

Participantes ajenos a CIPF

  • Torregrosa I
  • Giménez-Garzó C
  • Tomás P
  • Solís MÁ
  • Ramos C
  • Juan I
  • Puchades MJ
  • Saez G
  • Blasco ML
  • Miguel A

Grupos de Investigación

Abstract

Acute kidney injury (AKI) is a common complication after cardiac surgery and percutaneous coronary interventions which markedly worsens prognosis. In recent years, new early biomarkers of AKI have been identified, but many important aspects still remain to be solved. Klotho is a pleiotropic protein that acts as a paracrine and endocrine factor in multiple organs. Reduced renal Klotho levels have been show in several animal models of AKI. No study has been published in which Klotho was tested in humans as an early marker of AKI. The aim of this work is to assess the usefulness of measuring urinary Klotho for the early diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing cardiac surgery or coronary angiography.

Datos de la publicación

ISSN/ISSNe:
0211-6995, 1989-2284

NEFROLOGIA  SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ

Tipo:
Article
Páginas:
172-178
PubMed:
26300511

Citas Recibidas en Web of Science: 12

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Keywords

  • Acute kidney injury, Angiografía coronaria, Biomarcadores, Biomarkers, Cardiac surgery, Cirugía cardiaca, Coronary angiography, ELISA, Fracaso Renal Agudo, Klotho

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