Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review.
Autores de CIPF
Participantes ajenos a CIPF
- Jendelova P
Grupos de Investigación
Abstract
Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-organizing cultures of differentiating human embryonic stem cells or induced pluripotent stem cells, could recapitulate some aspects of the cytoarchitectural structure and function of the retina in vivo. 3D retinal organoids display huge potential for the investigation of the pathogenesis of monogenic hereditary eye diseases that are related to the malfunction or degeneration of photoreceptors or retinal ganglion cells by providing an effective in vitro tool with multiple applications. In combination with recent genome editing tools, 3D retinal organoids could also represent a reliable and renewable source of transplantable cells for personalized therapies. In this review, we describe the recent advances in human pluripotent stem cells-derived retinal organoids, determination of their histoarchitecture, complexity, and maturity. We also discuss their application as a means to decipher the pathogenesis of retinal diseases, as well as the main drawbacks and challenges. Stem Cells 2019;37:1496-1504.
Datos de la publicación
- ISSN/ISSNe:
- 1066-5099, 1549-4918
- Tipo:
- Article
- Páginas:
- 1496-1504
- DOI:
- 10.1002/stem.3089
- PubMed:
- 31617949
STEM CELLS WILEY
Citas Recibidas en Web of Science: 33
Documentos
- No hay documentos
Filiaciones
Keywords
- 3D organoids, Disease modeling, Induced pluripotent stem cells, Retinitis pigmentosa
Proyectos asociados
3D retinas derivadas de células iPS como herramienta para encontrar terapias eficaces para enfermedades hereditarias de la retina
Investigador Principal: DUNJA LUKOVIC
INSTITUTO DE SALUD CARLOS III . 2017
Estudio preclínico de potencias regenerativo de astrocitos derivados de células madre en tratamiento de lesión medular en ratón
Investigador Principal: SLAVEN ERCEG VUKICEVIC
INSTITUTO DE SALUD CARLOS III . 2019
Cerebellar cells derived from induced pluripotent stem cells in 3D culture generated from ARSACS patients as faithful disease model
Investigador Principal: SLAVEN ERCEG VUKICEVIC
FONDATION DE L'ATAXIE CHARLEVOIX-SAGUENAY . 2015