Portal de investigación
Cortical distribution of GABAergic interneurons is determined by migration time and brain size.
Autores de CIPF
Participantes ajenos a CIPF
- Mortimer N
- Yabut O
- Vogt D
- Pla R
Grupos de Investigación
Abstract
Cortical interneurons (CINs) originate in the ganglionic eminences (GEs) and migrate tangentially to the cortex guided by different attractive and repulsive cues. Once inside the cortex, the cellular and molecular mechanisms determining the migration of CINs along the rostrocaudal axis are less well understood. Here, we investigated the cortical distribution of CINs originating in the medial and caudal GEs at different time points. Using molecular and genetic labeling, we showed that, in the mouse, early- and late-born CINs (E12 versus E15) are differentially distributed along the rostrocaudal axis. Specifically, late-born CINs are preferentially enriched in cortical areas closer to their respective sites of origin in the medial or caudal GE. Surprisingly, our in vitro experiments failed to show a preferential migration pattern along the rostrocaudal axis for medial- or caudal-born CINs. Moreover, in utero transplantation experiments suggested that the rostrocaudal dispersion of CINs depends on the developmental stage of the host brain and is limited by the migration time and the increasing size of the developing brain. These data suggest that the embryonic expansion of the cortex contributes to the rostrocaudal distribution of CINs.
Datos de la publicación
- ISSN/ISSNe:
- 0950-1991, 1477-9129
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1242/dev.185033
- PubMed:
- 32586977
DEVELOPMENT COMPANY BIOLOGISTS LTD
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- Cortex, GABAergic interneurons, Migration, Neuron
Proyectos asociados
Señalización de NRG1 en circuitos corticales: información sobre las bases moleculares de la esquizofrenia
Investigador Principal: PIETRO FAZZARI
MINISTERIO DE ECON. Y COMPET. . 2018