Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies.

Autores de CIPF

• José Francisco Catalá Senent

  Autor

• Marta Rosa Hidalgo García

  Autor

• Pablo Malmierca Merlo

  Autor

• María De La Iglesia Vayá

  Autor

• 

  Francisco García García

  Autor

Participantes ajenos a CIPF

• Berenguer M
• Parthasarathy G
• Malhi H

Grupos de Investigación

• Unidad de Bioinformática y Bioestadística

  

  Jefe/a de Grupo

  Francisco García García

• Unidad Mixta CIPF-FISABIO de Imagen Biomédica

Abstract

Previous studies have described sex-based differences in the epidemiological and clinical patterns of non-alcoholic fatty liver disease (NAFLD); however, we understand relatively little regarding the underlying molecular mechanisms. Herein, we present the first systematic review and meta-analysis of NAFLD transcriptomic studies to identify sex-based differences in the molecular mechanisms involved during the steatosis (NAFL) and steatohepatitis (NASH) stages of the disease.

Keywords

• Computational biology, Non-alcoholic fatty liver disease, Precision medicine, Sex characteristics, Transcriptome profiling