Portal de investigación
Generation of three human iPSC lines from PLAN (PLA2G6-associated neurodegeneration) patients
Fecha de publicación:
Fecha Ahead of Print:
Autores de CIPF
Participantes ajenos a CIPF
- Correa-Vela, M
- Garcia-Navas, D
- Darling, A
- Villalon-Garcia, I
- Sanchez-Alcazar, JA
- Perez-Duenas, B
Grupos de Investigación
Abstract
The human iPSC cell lines, PLANFiPS1-Sv4F-1 (RCPFi004-A), PLANFiPS2-Sv4F-1 (RCPFi005-A), PLANFiPS3-Sv4F-1 RCPFi006-A), derived from dermal fibroblast from three patients suffering PLAN (PLA2G6-associated neurodegeneration; MIM 256600) caused by mutations in the PLA2G6 gene, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors. The pluripotency was assessed by immunocytochemistry and RT-PCR. Differentiation capacity was verified in vitro. This iPSC line can be further differentiated toward affected cells to better understand molecular mech-anisms of disease and pathophysiology.
Datos de la publicación
- ISSN/ISSNe:
- 1873-5061, 1876-7753
- Tipo:
- Article
- Páginas:
- 102338-102338
- PubMed:
- 34087982
Stem Cell Research ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 1
Documentos
- No hay documentos
Filiaciones
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