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Dietary PUFAs drive diverse system-level changes in lipid metabolism

Fecha de publicación: Fecha Ahead of Print:

Autores de CIPF

Participantes ajenos a CIPF

  • Furse, S
  • Virtue, S
  • Snowden, SG
  • Stevenson, PC
  • Chiarugi, D
  • Koulman, A

Grupos de Investigación

Abstract

Objective: Polyunsaturated fatty acid (PUFA) supplements have been trialled as a treatment for a number of conditions and produced a variety of results. This variety is ascribed to the supplements, that often comprise a mixture of fatty acids, and to different effects in different organs. In this study, we tested the hypothesis that the supplementation of individual PUFAs has system-level effects that are dependent on the molecular structure of the PUFA.Methods: We undertook a network analysis using Lipid Traffic Analysis to identify both local and system-level changes in lipid metabolism using publicly available lipidomics data from a mouse model of supplementation with FA(20:4n-6), FA(20:5n-3), and FA(22:6n-3); arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, respectively. Lipid Traffic Analysis is a new computational/bioinformatics tool that uses the spatial distribution of lipids to pinpoint changes or differences in control of metabolism, thereby suggesting mechanistic reasons for differences in observed lipid metabolism.Results: There was strong evidence for changes to lipid metabolism driven by and dependent on the structure of the supplemented PUFA. Phosphatidylcholine and triglycerides showed a change in the variety more than the total number of variables, whereas phosphatidylethanolamine and phosphatidylinositol showed considerable change in both which variables and the number of them, in a highly PUFA-dependent manner. There was also evidence for changes to the endogenous biosynthesis of fatty acids and to both the elongation and desaturation of fatty acids.Conclusions: These results show that the full biological impact of PUFA supplementation is far wider than any single-organ effect and implies that supplementation and dosing with PUFAs require a system-level assessment.(c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Datos de la publicación

ISSN/ISSNe:
2212-8778, 2212-8778

Molecular Metabolism  ELSEVIER SCIENCE BV

Tipo:
Article
Páginas:
101457-101457
PubMed:
35150907

Citas Recibidas en Web of Science: 5

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Keywords

  • Lipid metabolism; PUFA supplementation; Traffic analysis; Metabolic network

Financiación

BBSRC (BB/M027252/1)
BBSRC (BB/T014210/1)
BHF (RG/18/7/33636)
MRC (MRC_MC_UU_12012/2/RCUK)

Proyectos asociados

New players in human BAT differentiation and activation

Investigador Principal: STEFANIA CAROBBIO

COMMISSION OF EUROPEAN COMMUNITIES . 2021

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