Hepatic encephalopathy

Fecha de publicación: 23/06/2022

Autores de CIPF

Vicente Felipo Orts

Autor

Participantes ajenos a CIPF

Haussinger, D
Dhiman, RK
Gorg, B
Jalan, R
Kircheis, G
Merli, M
Montagnese, S
Romero-Gomez, M
Schnitzler, A
Taylor-Robinson, SD
Vilstrup, H

Grupos de Investigación

Laboratorio de Neurobiología

Jefe/a de Grupo

Vicente Felipo Orts

Abstract

Hepatic encephalopathy is a neuropsychiatric syndrome that occurs in patients with liver disease. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of hepatic encephalopathy, and discusses how this disorder affects the quality of life of patients. Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding, it is the most serious complication of decompensated liver cirrhosis. Ammonia and inflammation are major triggers for the appearance of HE, which in patients with liver cirrhosis involves pathophysiologically low-grade cerebral oedema with oxidative/nitrosative stress, inflammation and disturbances of oscillatory networks in the brain. Severity classification and diagnostic approaches regarding mild forms of HE are still a matter of debate. Current medical treatment predominantly involves lactulose and rifaximin following rigorous treatment of so-called known HE precipitating factors. New treatments based on an improved pathophysiological understanding are emerging.

Datos de la publicación

ISSN/ISSNe:: 2056-676X, 2056-676X
Tipo:: Article
Páginas:: 43-43
DOI:: 10.1038/s41572-022-00366-6
PubMed:: 35739133

Documentos

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Métricas

Filiaciones

Haussinger, D:: Heinrich Heine Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Med Fac, Dusseldorf, Germany

Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany
Dhiman, RK:: Sanjay Gandhi Postgrad Inst Med Sci, Dept Hepatol, Lucknow, Uttar Pradesh, India
Felipo, V:: Ctr Invest Principe Felipe, Lab Neurobiol, Valencia, Spain
Gorg, B:: Heinrich Heine Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Med Fac, Dusseldorf, Germany

Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany
Jalan, R:: UCL Med Sch, Div Med, Liver Failure Grp ILDH, Royal Free Campus, London, England

European Fdn Study Chron Liver Failure, Barcelona, Spain
Kircheis, G:: Univ Hosp Brandenburg, Brandenburg Med Sch, Dept Gastroenterol Diabetol & Hepatol, Brandenburg, Germany
Merli, M:: Univ Roma Sapienza, Dept Translat & Precis Med, Rome, Italy
Montagnese, S:: Univ Padua, Dept Med, Padua, Italy
Romero-Gomez, M:: Univ Seville, Virgen Rocio Univ Hosp, Inst Biomed Seville HUVR, UCM Digest Dis,HUVR,CSIC,US, Seville, Spain
Schnitzler, A:: Heinrich Heine Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany
Taylor-Robinson, SD:: Imperial Coll London, Dept Surg & Canc, St Marys Hosp Campus, London, England
Vilstrup, H:: Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark

Proyectos asociados

Mecanismos moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas.

Investigador Principal: VICENTE FELIPO ORTS

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2021

Molecular mechanisms of the neurological (cognitive and motor) alterations in hyperammonemia and hepatic encephalopathy. Therapeutic implications.