Portal de investigación
Molecular mechanisms of the neurological (cognitive and motor) alterations in hyperammonemia and hepatic encephalopathy. Therapeutic implications.
Datos básicos
- Código Financiador:
- Año inicial:
- 2022
- Año final:
- 2026
Documentos
- No hay documentos
Participantes
Grupos de Investigación
Financiadores
Resultados del Proyecto
A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats.
Article. 10.1186/s12974-024-03310-5. 2024
Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment.
Bäckström T; (...); Felipo V
Article. 10.1016/j.neubiorev.2024.105668. 2024
Contribution of extracellular vesicles to neuroinflammation and cognitive and motor deficits in hyperammonemia and hepatic encephalopathy
Izquierdo-Altarejos, P, Felipo, V
Review. 10.20517/evcna.2023.66. 2024
Enhanced Activation of the S1PR2-IL-1ß-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Sancho-Alonso M; (...); Felipo V
Article. 10.3390/ijms242417251. 2023
Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia
Arenas, YM; (...); Felipo, V
Article. 10.3390/ijms231911770. 2022
Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNF alpha Content
Izquierdo-Altarejos, P, Martinez-Garcia, M, Felipo, V
Article. 10.3389/fimmu.2022.921947. 2022
Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats.
Izquierdo-Altarejos P, Martínez-García M, Felipo V
Article. 10.1007/s00018-023-04750-7. 2023
Extracellular vesicles from L. paracasei improve neuroinflammation, GABA neurotransmission and motor incoordination in hyperammonemic rats.
Article. 10.1016/j.bbi.2024.10.002. 2025
Extracellular vesicles from mesenchimal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats
Izquierdo-Altarejos, P; (...); Felipo, V
Meeting Abstract. 2022
Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy.
Mincheva G; (...); Llansola M
Article. 10.1186/s13287-024-04076-6. 2024
Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats.
Izquierdo-Altarejos P; (...); Felipo V
Article. 10.1186/s12974-022-02688-4. 2023
Extracellular Vesicles from Mesenchymal Stem Cells Reverse Neuroinflammation and Restore Motor Coordination in Hyperammonemic Rats.
Izquierdo-Altarejos P; (...); Felipo V
Article. 10.1007/s11481-024-10153-7. 2024
Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.
Article. 10.1111/liv.15782. 2023
Golexanolone, a GABA receptor-modulating steroid antagonist, improves peripheral inflammation, fatigue, locomotor gait, motor incoordination and short-term memory in rats with cholestasis and hepatic encephalopathy due to bile duct ligation
Izquierdo-Altarejos, P; (...); Felipo, V
Meeting Abstract. 2023
Golexanolone, a GABA(A) receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation
Mincheva, G; (...); Felipo, V
Article. 10.1111/cns.13926. 2022
Hepatic encephalopathy: investigational drugs in preclinical and early phase development.
Balzano T; (...); Felipo V
Article. 10.1080/13543784.2023.2277386. 2023
Hyperammonemia Alters the Function of AMPA and NMDA Receptors in Hippocampus: Extracellular cGMP Reverses Some of These Alterations
Sancho-Alonso, M; (...); Teruel-Marti, V
Article. 10.1007/s11064-022-03588-y. 2022
Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP
Sancho-Alonso, M; (...); Felipo, V
Article. 10.1007/s12035-022-02803-9. 2022
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
Arenas, YM; (...); Felipo, V
Article. 10.1186/s40659-024-00504-2. 2024
Intracellular and extracelluar cyclic GMP in the brain and the hippocampus.
Taoro-González L; (...); Felipo V
Article. 10.1016/bs.vh.2021.11.006. 2022
Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy
Ballester, MP; (...); Montoliu, C
Article. 10.1038/s41598-022-06416-z. 2022
Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease.
Fiorillo A; (...); Montoliu C
Article. 10.3390/ijms241210407. 2023
Minimal hepatic encephalopathy is associated to alterations in eye movements
Casanova-Ferrer, F; (...); Montoliu, C
Article. 10.1038/s41598-022-21230-3. 2022
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications
Llansola, M; (...); Felipo, V
Review. 10.3389/fphar.2024.1358323. 2024
Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases.
Izquierdo-Altarejos P, Moreno-Manzano V, Felipo V
Article. 10.4103/1673-5374.375301. 2024
Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
Leone P; (...); Felipo V
Article. 10.1111/ene.15935. 2023
Plasma Extracellular Vesicles Play a Role in Immune System Modulation in Minimal Hepatic Encephalopathy.
Gallego JJ; (...); Montoliu C
Article. 10.3390/ijms232012335. 2022
Potential Neuroprotective Role of Sugammadex: A Clinical Study on Cognitive Function Assessment in an Enhanced Recovery After Cardiac Surgery Approach and an Experimental Study
Muedra, V; (...); Hernandez-Rabaza, V
Article. 10.3389/fncel.2022.789796. 2022
Preface for the Vicente Felipo Honorary Issue of Neurochemical Research.
Editorial Material. 10.1007/s11064-024-04139-3. 2024
Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation
Leone, P; (...); Llansola, M
Article. 10.3390/biomedicines10061263. 2022
Role of peripheral inflammation in minimal hepatic encephalopathy.
Llansola M; (...); Felipo V
Article. 10.1007/s11011-024-01417-5. 2024
Sustained Hyperammonemia Activates NF-?B in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy.
Article. 10.1007/s12035-023-03264-4. 2023
The S1PR2-CCL2-BDNF-TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia
Arenas, YM; (...); Felipo, V
Article. 10.1111/nan.12799. 2022