1. Inicio
  2. Publicaciones
  3. Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.

Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.

Fecha de publicación: Fecha Ahead of Print:

Autores de CIPF

Participantes ajenos a CIPF

  • Mincheva G
  • Martinez-Garcia M

Grupos de Investigación

Abstract

Neuroinflammation in the cerebral cortex of patients who died with liver cirrhosis and neuroinflammation, and neuronal death in the cerebellum of patients who died with steatohepatitis or cirrhosis, were reported. Hippocampal neuroinflammation could contribute to cognitive decline in patients with liver disease, but this has yet to be studied. The study aims were to assess if hippocampus from patients who died with steatohepatitis or cirrhosis showed: (i) glial activation, (ii) altered cytokine content, (iii) immune cell infiltration, (iv) neuronal apoptosis and (v) neuronal loss.

Datos de la publicación

ISSN/ISSNe:
1351-5101, 1468-1331

EUROPEAN JOURNAL OF NEUROLOGY  WILEY

Tipo:
Article
Páginas:
3032-3046
PubMed:
37340928

Citas Recibidas en Web of Science: 10

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • chronic liver disease, glial activation, lymphocyte infiltration, neuronal loss

Campos de Estudio

Proyectos asociados

Mecanismos moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas.

Investigador Principal: VICENTE FELIPO ORTS

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2021

Molecular mechanisms of the neurological (cognitive and motor) alterations in hyperammonemia and hepatic encephalopathy. Therapeutic implications.

Investigador Principal: VICENTE FELIPO ORTS

CONSELLERIA DE EDUCACION . 2022

Compartir