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Hepatic encephalopathy: investigational drugs in preclinical and early phase development.

Fecha de publicación: Fecha Ahead of Print:

Autores de CIPF

Grupos de Investigación

Abstract

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome, in patients with liver disease, which affects life quality and span. Current treatments are lactulose or rifaximin, acting on gut microbiota. Treatments aiming ammonia levels reduction have been tested with little success.

Datos de la publicación

ISSN/ISSNe:
1354-3784, 1744-7658

EXPERT OPINION ON INVESTIGATIONAL DRUGS  Taylor & Francis

Tipo:
Article
Páginas:
1-15
PubMed:
37902074

Citas Recibidas en Web of Science: 8

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Keywords

  • Hepatic encephalopathy, hyperammonemia, immune system, microbiota, neuroinflammation, neurotransmission, peripheral inflammation

Campos de Estudio

Proyectos asociados

Mecanismos moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas.

Investigador Principal: VICENTE FELIPO ORTS

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2021

Molecular mechanisms of the neurological (cognitive and motor) alterations in hyperammonemia and hepatic encephalopathy. Therapeutic implications.

Investigador Principal: VICENTE FELIPO ORTS

CONSELLERIA DE EDUCACION . 2022

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