Recent developments in adipose tissue-secreted factors and their target organs.

Autores de CIPF

• Jaime Navarro Pérez

  Autor

• 

  Antonio Vidal Puig

  Autor

• 

  Stefania Carobbio

  Autor

Grupos de Investigación

• Laboratorio de Obesidad, Diabetes y Cormobilidades

  

  Jefe/a de Grupo

  Stefania Carobbio

• Unidad Mixta CIPF-CAMBRIDGE de Obesidad y Regulación Metabólica

  

  Jefe/a de Grupo

  Antonio Vidal Puig

Abstract

The white adipose tissue's primary roles are to store and mobilise energy, which is very different from the brown adipose tissue's function of using fuel to generate heat and maintain the body temperature. The adipose tissues (ATs), co-ordinately with the other organs, sense energetic demands and inform of their reserves before embarking on energetically demanding physiological functions. It is not surprising that ATs exhibit highly integrated regulatory mechanisms mediated by a diversified secretome, including adipokines, lipokines, metabolites and a repertoire of extracellular miRNAs that contribute to integrating the function of the AT niche and connect the AT through paracrine and endocrine effects with the whole organism. Characterising the adipose secretome, its changes in health and disease, regulation by ageing and gender and their contribution to energy homoeostasis is necessary to optimise its use for personalised strategies to prevent or reverse metabolic diseases.