Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.

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Autores de CIPF

Participantes ajenos a CIPF

  • Amin A
  • Badenes M
  • Tüshaus J
  • de Carvalho É
  • Burbridge E
  • Faísca P
  • Trávnícková K
  • Barros A
  • Domingos PM
  • Moita LF
  • Maguire S
  • Stríšovský K
  • Ortega FJ
  • Fernández-Real JM
  • Lichtenthaler SF
  • Adrain C

Grupos de Investigación

Abstract

The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its importance for the immune system and epithelial tissues is well-documented, little is known about the role of ADAM17 in metabolic homeostasis. The purpose of this study was to determine the impact of ADAM17 expression, specifically in adipose tissues, on metabolic homeostasis.

Datos de la publicación

ISSN/ISSNe:
2212-8778, 2212-8778

Molecular Metabolism  ELSEVIER SCIENCE BV

Tipo:
Article
Páginas:
101731-101731
PubMed:
37121509

Citas Recibidas en Web of Science: 2

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Keywords

  • ADAM17/TACE, Adipose tissue, Beta-adrenoceptor signalling, Cold challenge, Metabolism, Obesity, Semaphorin4B Sema4b, Thermogenesis

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