Portal de investigación
Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning.
Fecha de publicación:
Fecha Ahead of Print:
Autores de CIPF
Participantes ajenos a CIPF
- Castellá M
- Blasco-Roset A
- Peyrou M
- Gavaldà-Navarro A
- Villarroya J
- Quesada-López T
- Lorente-Poch L
- Sancho J
- Szymczak F
- Piron A
- Rodríguez-Fernández S
- Goday A
- Domingo P
- Giralt M
- Eizirik DL
- Villarroya F
- Cereijo R
Grupos de Investigación
Abstract
Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulation of splicing machinery components and splicing regulatory factors in browned adipose tissue from patients, with upregulation of a few genes encoding RNA-binding proteins potentially involved in splicing regulation. These changes were also observed in cell culture models of human brown adipocyte differentiation, confirming a potential involvement of splicing in the cell-autonomous control of adipose browning. The coordinated changes in splicing are associated with a profound modification in the expression levels of splicing-driven transcript isoforms for genes involved in the specialized metabolism of brown adipocytes and those encoding master transcriptional regulators of adipose browning. Splicing control appears to be a relevant component of the coordinated gene expression changes that allow human adipose tissue to acquire a brown phenotype.
Datos de la publicación
- ISSN/ISSNe:
- 2589-0042, 2589-0042
- Tipo:
- Article
- Páginas:
- 106847-106847
- PubMed:
- 37250773
iScience CELL PRESS
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- Biopsy sample, Specialized functions of cells, Transcriptomics
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