Portal de investigación
Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
Fecha de publicación:
Autores de CIPF
Participantes ajenos a CIPF
- Gupta, S
- Lytvynchuk, L
- Ardan, T
- Studenovska, H
- Faura, G
- Eide, L
- Znaor, L
- Stieger, K
- Motlik, J
- Bharti, K
- Petrovski, G
Grupos de Investigación
Abstract
The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells.
Datos de la publicación
- ISSN/ISSNe:
- 2227-9059, 2227-9059
- Tipo:
- Review
- Páginas:
- -
- PubMed:
- 36830851
Biomedicines MDPI AG
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- retinal pigment epithelium (RPE); differentiation; stem cells; cell therapy; age-related macular degeneration
Financiación
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