Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives.

Fecha de publicación: 27/11/2023 Fecha Ahead of Print: 20/11/2023

Autores de CIPF

Amparo Galán Albiñana

Autor

Participantes ajenos a CIPF

Gómez-Álvarez M
Bueno-Fernandez C
Rodríguez-Eguren A
Francés-Herrero E
Agustina-Hernández M
Faus A
Gisbert Roca F
Martínez-Ramos C
Pellicer A
Ferrero H
Cervelló I

Grupos de Investigación

Laboratorio de Neuroendocrinología Molecular

Jefe/a de Grupo

Deborah J Burks

Abstract

The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve reproductive healthcare. Human endometrial organoids (hEOs) are emerging as powerful models for translational research and personalized medicine. However, most hEOs are cultured in a 3D microenvironment that significantly differs from the human endometrium, limiting their applicability in bioengineering. This study presents a hybrid endometrial-derived hydrogel that combines the rigidity of PuraMatrix (PM) with the natural scaffold components and interactions of a porcine decellularized endometrial extracellular matrix (EndoECM) hydrogel. This hydrogel provides outstanding support for hEO culture, enhances hEO differentiation efficiency due to its biochemical similarity with the native tissue, exhibits superior in vivo stability, and demonstrates xenogeneic biocompatibility in mice over a 2-week period. Taken together, these attributes position this hybrid endometrial-derived hydrogel as a promising biomaterial for regenerative treatments in reproductive medicine.

Datos de la publicación

ISSN/ISSNe:: 2192-2640, 2192-2659
Tipo:: Article
Páginas:: -
DOI:: 10.1002/adhm.202303838
PubMed:: 37983675

Documentos

No hay documentos

Métricas

Filiaciones

Gómez-Álvarez M:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain
Bueno-Fernandez C:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain

Universitat de València, Department of Pediatrics, Obstetrics and Gynaecology, Valencia, 46010, Spain
Rodríguez-Eguren A:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain
Francés-Herrero E:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain

Universitat de València, Department of Pediatrics, Obstetrics and Gynaecology, Valencia, 46010, Spain
Agustina-Hernández M:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain
Faus A:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain
Gisbert Roca F:: Universitat Politècnica de València, Centre for Biomaterials and Tissue Engineering, Valencia, 46022, Spain
Martínez-Ramos C:: Universitat Politècnica de València, Centre for Biomaterials and Tissue Engineering, Valencia, 46022, Spain

Unitat Predepartamental de Medicina, Universitat Jaume I, Castellón de la Plana, 12071, Spain
Galán A:: Laboratory of Neuroendocrinology, Prince Felipe Research Center (CIPF), Valencia, 46012, Spain

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, 28029, Spain
Pellicer A:: IVIRMA Global Research Alliance, IVIRMA, Rome, Roma, 00197, Italy
Ferrero H:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain
Cervelló I:: IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, 46026, Spain

Keywords

bioengineering, endometrium, extracellular matrix hydrogel, organoids

Proyectos asociados

Solicitud GE Fede Lucantoni. Ento-cancer: Estudio de la entosis en cáncer humano. Relevancia del canibalismo celular en la agresividad de los tumores sólidos.

Investigador Principal: FEDERICO LUCANTONI

CONSELLERIA DE EDUCACION . 2023

THE FUTURE OF BIOMEDICAL RESEARCH (FBR) CIPF LECTURE SERIES

Investigador Principal: FRANCISCO GARCÍA GARCÍA

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