Adipose tissue-derived stem cells, in vivo and in vitro models for metabolic diseases.

Autores de CIPF

• 

  Stefania Carobbio

  Autor

Participantes ajenos a CIPF

• Navarro-Perez J

Grupos de Investigación

• Laboratorio de Obesidad, Diabetes y Cormobilidades

  

  Jefe/a de Grupo

  Stefania Carobbio

• Unidad Mixta CIPF-CAMBRIDGE de Obesidad y Regulación Metabólica

  

  Jefe/a de Grupo

  Antonio Vidal Puig

Abstract

The primary role of adipose tissue stem cells (ADSCs) is to support the function and homeostasis of adipose tissue in physiological and pathophysiological conditions. However, when ADSCs become dysfunctional in diseases such as obesity and cancer, they become impaired, undergo signalling changes, and their epigenome is altered, which can have a dramatic effect on human health. In more recent years, the therapeutic potential of ADSCs in regenerative medicine, wound healing, and for treating conditions such as cancer and metabolic diseases has been extensively investigated with very promising results. ADSCs have also been used to generate two-dimensional (2D) and three-dimensional (3D) cellular and in vivo models to study adipose tissue biology and function as well as intracellular communication. Characterising the biology and function of ADSCs, how it is altered in health and disease, and its therapeutic potential and uses in cellular models is key for designing intervention strategies for complex metabolic diseases and cancer.