Mecanismos moleculares y cerebrales de las alteraciones cognitivas y motoras en hiperamonemia y encefalopatía hepática. Implicaciones terapeúticas y diagnósticas

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

Tarazona, S; (...); Felipo, V

Article. 10.1007/s10565-020-09572-y. 2021

A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects

Tarazona, S; (...); Llansola, M

Article. 10.1021/acschemneuro.9b00304. 2019

A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease

Gimenez-Garzo, C; (...); Montoliu, C

Article. 10.3390/jcm10132806. 2021

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Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Silvestri, A; (...); Fecke, W

Review. 10.1016/j.drudis.2021.02.024. 2021

Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat

Agusti, A; (...); Sanz, Y

Article. 10.1007/s12035-021-02462-2. 2021

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Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Malaguarnera, M; (...); Felipo, V

Article. 10.3389/fphar.2019.00132. 2019

Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice

Garcia-Pardo, MP; (...); Aguilar, MA

Article. 10.1016/j.niox.2020.03.001. 2020

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-?ß pathway.

Arenas YM; (...); Felipo V

Article. 10.1186/s12974-020-01941-y. 2020

Cirrhotic patients with minimal hepatic encephalopathy have increased capacity to eliminate superoxide and peroxynitrite in lymphocytes, associated with cognitive impairment

Gimenez-Garzo, C; (...); Montoliu, C

Article. 10.1080/10715762.2017.1420183. 2018

Characterizing sensory thresholds and autonomic dysfunction in cirrhotic patients with minimal hepatic encephalopathy

Rega, D; (...); Montoliu, C

Meeting Abstract. 2021

Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP

Cabrera-Pastor A; (...); Felipo V

Review. 10.1016/j.neuropharm.2019.01.011. 2019

Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved

Cabrera-Pastor, A; (...); Felipo, V

Article. 10.1016/j.bbadis.2017.10.031. 2018

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: Reversed by anti-TNF-alpha treatment

Balzano, T; (...); Felipo, V

Article. 10.1016/j.jhep.2019.01.008. 2020

Decreased cognitive performance is associated with reduced resting state connectivity and gray matter atrophy in patients with minimal hepatic encephalopathy

Garcia-Garcia, R; (...); Montoliu, C

Meeting Abstract. 10.1016/S0618-8278(19)30863-1. 2019

Decreased Cognitive Performance Is Associated With Reduced Resting State Connectivity and Gray Matter Atrophy in Patients With Minimal Hepatic Encephalopathy

Garcia-Garcia, R; (...); Montoliu, C

Meeting Abstract. 10.14309/01.ajg.0000582196.79157.8c. 2019

Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms

Gomez-Gimenez, B; (...); Llansola, M

Article. 10.1007/s12640-017-9823-9. 2018

Differential role of interleukin-1 beta in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats

Taoro-González L; (...); Felipo V

Article. 10.1096/fj.201900230RR. 2019

Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points

Gomez-Gimenez, B; (...); Felipo, V

Article. 10.1021/acschemneuro.7b00364. 2018

Epigenetic modification of urea cycle enzymes in NAFLD animal models and patients: Implications for novel therapeutic approaches

De Chiara, F; (...); Thomsen, KL

Meeting Abstract. 2018

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P; (...); Gribbon, P

Article. 10.1177/2472555218816276. 2019

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms

Taoro-Gonzalez L; (...); Felipo V

Article. 10.1007/s12035-018-1387-z. 2019

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats

Izquierdo-Altarejos, P; (...); Felipo, V

Article. 10.3390/cells9030572. 2020

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Histological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic Steatohepatitis

Balzano T; (...); Felipo V

Article. 10.1093/jnen/nly061. 2018

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

Taoro-Gonzalez, L; (...); Felipo, V

Article. 10.1186/s12974-018-1082-z. 2018

Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission

Garcia-Garcia, R; (...); Felipo, V

Article. 10.1111/jnc.14941. 2020

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

Cabrera-Pastor, A; (...); Felipo, V

Article. 10.1016/j.bbi.2017.12.013. 2018

Inhibition of gamma-Secretase Leads to an Increase in Presenilin-1

Sogorb-Esteve, A; (...); Saez-Valero, J

Article. 10.1007/s12035-017-0705-1. 2018

Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus

Garcia-Garcia, R; (...); Montoliu, C

Article. 10.1038/s41598-018-27978-x. 2018

Lymphocyte infiltration, glial activation and neuronal loss in cerebellum of patients with different stages of chronic liver disease

Balzano, T; (...); Felipo, V

Meeting Abstract. 2019

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy

San Martin-Valenzuela, C; (...); Montoliu, C

Article. 10.3390/jcm9072154. 2020

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Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients

Rubio, T; (...); Montoliu, C

Article. 10.1038/s41598-020-80941-7. 2021

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Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients

Rubio, T; (...); Montoliu, C

Meeting Abstract. 2021

Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function

Rega, D; (...); Montoliu, C

Article. 10.3390/jcm10020239. 2021

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Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications

Cabrera-Pastor A; (...); Felipo V

Review. 10.1111/apha.13270. 2019

Rifaximin improves neuroinflammation and neurotransmission in cerebellum and hippocampus of rats with mild liver damage

Ivaylova, G; (...); Felipo, V

Meeting Abstract. 2021

Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage

Balzano, T; (...); Felipo, V

Article. 10.3390/biomedicines9081002. 2021

Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on the rewarding properties of MDMA in mice

Garcia-Pardo MP; (...); Aguilar MA

Article. 10.1111/ejn.14190. 2019

Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy

Mangas-Losada, A; (...); Felipo, V

Article. 10.1186/s12967-019-2046-5. 2019

Selective improvement by rifaximin of changes in the inmunophenotype in patients who improve minimal hepatic encephalopathy

Ballester, MP; (...); Montoliu, C

Meeting Abstract. 10.1016/S0618-8278(19)31325-8. 2019

Sleep study with actigraphy in patients affected by cirrhosis with and without minimal hepatic encephalopathy

Ipiens, C; (...); Montoliu, C

Meeting Abstract. 2021

Sustained hyperammonemia induces TNF-a in glial cells and Purkinje neurons by activating the TNFR1-NF-kappa B pathway

Ortiz, YMA; (...); Felipo, V

Meeting Abstract. 2021

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway

Balzano, T; (...); Felipo, V

Article. 10.1186/s12974-020-01746-z. 2020

Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction

Urios, A; (...); Montoliu, C

Article. 10.1038/s41598-019-53136-y. 2019

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons

Balzano, T; (...); Felipo, V

Article. 10.1038/s41598-018-21399-6. 2018

The Dual Role of the GABA(A) Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats

Malaguarnera, M; (...); Felipo, V

Article. 10.3390/ijms22136772. 2021

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The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis

Zarantonello L; (...); Montagnese S

Article. 10.1111/liv.14046. 2019

The influence of hepatic encephalopathy (HE) history, HE status and neuropsychological test type on learning ability in patients with cirrhosis

Zarantonello, L; (...); Montagnese, S

Meeting Abstract. 10.1016/j.dld.2018.11.123. 2019

Urea cycle dysregulation in non-alcoholic fatty liver disease

De Chiara, F; (...); Thomsen, KL

Article. 10.1016/j.jhep.2018.06.023. 2018