1. Inicio
  2. Publicaciones
  3. Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Fecha de publicación: Fecha Ahead of Print:

Autores de CIPF

Participantes ajenos a CIPF

  • Silvestri, A
  • Stechmann, B
  • Fecke, W

Grupos de Investigación

Abstract

The success of preclinical drug discovery strongly relies on the ability of experimental models to resemble human pathophysiology. The number of compounds receiving approval for clinical use is limited, and this has led to the development of more physiologically relevant cellular models aimed at making preclinical results more prone to be successfully translated into clinical use. In this review, we summarize the technologies available in the field of high-throughput screening (HTS) using complex cellular models, and describe collaborative initiatives, such as EU-OPENSCREEN, which can efficiently support researchers to easily access state-of-the-art chemical biology platforms for improving the drug discovery process.

Datos de la publicación

ISSN/ISSNe:
1359-6446, 1878-5832

DRUG DISCOVERY TODAY  ELSEVIER SCI LTD

Tipo:
Review
Páginas:
1369-1381
PubMed:
33677144

Citas Recibidas en Web of Science: 7

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Campos de Estudio

Proyectos asociados

Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond

Investigador Principal: MARIA JESUS VICENT DOCON

COMMISSION OF EUROPEAN COMMUNITIES . 2019

Bases moleculares de las alteraciones neurológicas (cognitivas y motoras) en hiperamonemia y encefalopatía hepática. Implicaciones terapéuticas

Investigador Principal: VICENTE FELIPO ORTS

MINISTERIO DE ECON. Y COMPET. . 2018

Mecanismos moleculares y cerebrales de las alteraciones cognitivas y motoras en hiperamonemia y encefalopatía hepática. Implicaciones terapeúticas y diagnósticas

Investigador Principal: VICENTE FELIPO ORTS

CONSELLERIA DE EDUCACION . 2018

RTC-2017-6600-1 Desarrollo de una plataforma de terapia génica para enfermedades genéticas renales

Investigador Principal: MARIA JESUS VICENT DOCON

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2018

Desarrollo de terapias tópicas basadas en sistemas de transporte polipeptídicos

Investigador Principal: MARIA JESUS VICENT DOCON

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2018

SENSITIZING PANCREATIC CANCER TO IMMUNOTHERAPY WITH MULTIMODAL PRECISION NANOMEDICINES

Investigador Principal: MARIA JESUS VICENT DOCON

FUNDACIÓN LA CAIXA . 2019

Molecular Machines Functioning in Cells

Investigador Principal: MARIA JESUS VICENT DOCON

COMMISSION OF EUROPEAN COMMUNITIES . 2020

Aproximación sinérgica al desarrollo de terapias para tumores metastásicos y desórdenes neurodegenarativos utilizando conjugados polipetídicos versátiles

Investigador Principal: MARIA JESUS VICENT DOCON

MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES . 2020

Identification and modelling of molecular and cellular events of the inmune response associated to the appearence of minimal hepatic encephalopaty in cirrhotic patients

Investigador Principal: VICENTE FELIPO ORTS

FUNDACION RAMON ARECES . 2019

Novel therapeutic approaches in achondroplasia - TV3 Fundació La Marató. Proyecto de la Dra. Mª Ángela Nieto en el que colabora Mª Jesus Vicent y otros IPs del CIPF

FUNDACION LA MARATO DE TV3 . 2020

Compartir