Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond

A High-Throughput Chemical Screen in DJ-1 beta Mutant Flies Identifies Zaprinast as a Potential Parkinson's Disease Treatment

Sanz, FJ; (...); Paricio, N

Article. 10.1007/s13311-021-01134-2. 2021

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A Hyaluronic Acid Demilune Scaffold and Polypyrrole-Coated Fibers Carrying Embedded Human Neural Precursor Cells and Curcumin for Surface Capping of Spinal Cord Injuries

Elkhenany, H; (...); Manzano, VM

Article. 10.3390/biomedicines9121928. 2021

A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

Hernández-Montoto A; (...); Sancenón F

Article. 10.1039/c9cc04260a. 2019

A Rapid, Convergent Approach to the Identification of Exosome Inhibitors in Breast Cancer Models.

Andreu Z; (...); Vicent MJ

Article. 10.7150/ntno.73606. 2023

A rationally designed self-immolative linker enhances the synergism between a polymer-rock inhibitor conjugate and neural progenitor cells in the treatment of spinal cord injury.

Giraldo E; (...); Moreno-Manzano V

Article. 10.1016/j.biomaterials.2021.121052. 2021

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A targeted polypeptide-based nanoconjugate as a nanotherapeutic for alcohol-induced neuroinflammation.

Cuesta, Carlos Manuel; (...); Guerri, Consuelo

Article. 10.1016/j.nano.2021.102376. 2021

Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Silvestri, A; (...); Fecke, W

Review. 10.1016/j.drudis.2021.02.024. 2021

BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy

Sancho, M, Orzaez, M

Editorial Material. 10.1080/23723556.2020.1859918. 2021

Clinically-relevant and predictive cancer models for nanomedicine evaluation

Satchi-Fainaro, R, Florindo, HF, Vicent, MJ

Editorial Material. 10.1016/j.addr.2022.114140. 2022

Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer.

Estepa-Fernández A; (...); Martínez-Máñez R

Article. 10.1016/j.phrs.2022.106628. 2023

Current hurdles to the translation of nanomedicines from bench to the clinic

Dordevic, S; (...); Vicent, MJ

Review. 10.1007/s13346-021-01024-2. 2022

Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression

Arroyo-Crespo JJ; (...); Vicent MJ

Article. 10.1002/ijc.32270. 2019

DEPLETION OF CD206(HIGH) TUMOUR-ASSOCIATED MACROPHAGES USING A NANOCONJUGATE LIMITS TUMOUR BURDEN & DISSEMINATION IN METASTATIC TRIPLE NEGATIVE BREAST CANCER IN MICE

Lepland, A; (...); Scodeller, P

Meeting Abstract. 10.1136/jitc-2021-ITOC8.11. 2021

Dinoponera quadriceps venom as a source of active agents against Staphylococcus aureus

Rocha, LQ; (...); Martins, AMC

Article. 10.1016/j.toxicon.2020.11.003. 2021

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

Cordoba-David, G; (...); Ramos, AM

Article. 10.1038/s41598-020-58974-9. 2020

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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P; (...); Gribbon, P

Article. 10.1177/2472555218816276. 2019

Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

Moura, LIF; (...); Florindo, HF

Review. 10.1039/c9mh00628a. 2019

Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Candela-Noguera, V; (...); Martinez-Manez, R

Article. 10.3390/nano11051298. 2021

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High- throughput screening using a Drosophila model of Parkinson's disease

Lopez, FJ; (...); Paricio, N

Meeting Abstract. 2019

Higher-order interfiber interactions in the self-assembly of benzene-1,3,5-tricarboxamide-based peptides in water

Zagorodko, O; (...); Vicent, MJ

Article. 10.1039/d1py00304f. 2021

Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy

Vivo-Llorca, G; (...); Martinez-Manez, R

Article. 10.2147/IJN.S323802. 2022

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Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Bonilla, P; (...); Moreno-Manzano, V

Article. 10.3390/ijms22115966. 2021

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Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases

Soriano-Teruel, PM; (...); Orzaez, M

Article. 10.1038/s41419-021-04420-1. 2021

Identification of NLRP3(PYD) Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity

Ghafary, SM; (...); Hosseinkhani, S

Article. 10.3390/ijms23031651. 2022

In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy

Fernandez, Y; (...); Vicent, MJ

Article. 10.1002/adhm.202101544. 2022

Janus Gold Nanostars-Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery

Hernández Montoto A; (...); Sancenón F

Article. 10.1002/chem.201900750. 2019

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Van Lysebetten, D; (...); De Geest, BG

Article. 10.1021/acsami.0c20607. 2021

Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis.

Lucendo E; (...); Orzáez M

Article. 10.1073/pnas.2008885117. 2020

MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Vivo-Llorca, G; (...); Martinez-Manez, R

Article. 10.1002/chem.202001579. 2020

Multi-Omic Approaches to Breast Cancer Metabolic Phenotyping: Applications in Diagnosis, Prognosis, and the Development of Novel Treatments

Gomez-Cebrian, N; (...); Pineda-Lucena, A

Review. 10.3390/cancers13184544. 2021

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Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy

Garcia-Fernandez, A; (...); Martinez-Manez, R

Article. 10.3390/pharmaceutics14071495. 2022

Nanomedicine for the Treatment of Advanced Prostate Cancer

Vicente-Ruiz, S; (...); Vicent, MJ

Review. 10.1002/adtp.202000136. 2021

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Lerida-Viso, A; (...); Martinez-Manez, R

Article. 10.1016/j.phrs.2022.106356. 2022

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1016/j.jconrel.2021.02.005. 2021

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Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury

Tejedor, S; (...); Vicent, MJ

Article. 10.1002/adhm.202002121. 2021

Polymer-based non-viral vectors for gene therapy in the skin

Tortajada, L, Felip-Leon, C, Vicent, MJ

Review. 10.1039/d1py01485d. 2022

Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders.

Conejos-Sánchez I; (...); Vicent MJ

Article. 10.1039/c9nr06187h. 2020

Polypeptide-based conjugates as versatile therapeutics as single agents or in combination therapy

Zagorodko, O; (...); Vicent, M

Meeting Abstract. 2019

Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

Dolz-Pérez I; (...); Vicent MJ

Article. 10.1016/j.jconrel.2019.12.016. 2020

Polypeptides as building blocks for image-guided nanotherapies

Conejos-Sanchez, I; (...); Vicent, MJ

Article. 10.1016/j.cobme.2021.100323. 2021

Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic.

Galiana I; (...); Orzáez M

Article. 10.1016/j.jconrel.2020.04.045. 2020

Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

Monteiro ML; (...); Martins AMC

Article. 10.1016/j.ejmech.2022.114624. 2022

Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue

Lozano-Torres, B; (...); Martinez-Manez, R

Article. 10.1002/anie.202004142. 2020

Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives

Geo, HN; (...); Kiew, LV

Review. 10.1016/j.jconrel.2022.01.033. 2022

Senolysis Reduces Senescence in Veins and Cancer Cell Migration

Estepa-Fernandez, A; (...); Martinez-Manez, R

Article. 10.1002/adtp.202100149. 2021

Split-luciferase complementary assay of NLRP3 PYD-PYD interaction indicates inflammasome formation during inflammation.

Isazadeh M; (...); Hosseinkhani S

Article. 10.1016/j.ab.2021.114510. 2022

Synthetic polypeptides for drug and gene delivery, and tissue engineering.

Yin L; (...); Vicent MJ

Editorial Material. 10.1016/j.addr.2021.113995. 2021

Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment.

García-Fernández A; (...); Martínez-Máñez R

Article. 10.1016/j.jconrel.2021.07.010. 2021

Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1126/sciadv.abf9180. 2021

Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide

Lepland, A; (...); Scodeller, P

Article. 10.1021/acs.molpharmaceut.0c00226. 2020

The chemistry of senescence

Lozono-Torres, B; (...); Sancenon, F

Review. 10.1038/s41570-019-0108-0. 2019

The generation of stabilized supramolecular nanorods from star-shaped polyglutamates

Zagorodko, O, Nebot, VJ, Vicent, MJ

Article. 10.1039/c9py01442j. 2020

The past, present, and future of breast cancer models for nanomedicine development

Boix-Montesinos, P; (...); Vicent, MJ

Review. 10.1016/j.addr.2021.03.018. 2021

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Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation.

Melnyk T; (...); Vicent MJ

Article. 10.1016/j.addr.2020.10.007. 2020

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Transplantation of Human-Fetal-Spinal-Cord-Derived NPCs Primed with a Polyglutamate-Conjugated Rho/Rock Inhibitor in Acute Spinal Cord Injury.

Giraldo E; (...); Moreno Manzano V

Article. 10.3390/cells11203304. 2022

Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen

Marti-Centelles, R; (...); Escuder, B

Article. 10.1021/acsabm.0c01422. 2021

Understanding MCL1: from cellular function and regulation to pharmacological inhibition

Sancho, M; (...); Orzaez, M

Review. 10.1111/febs.16136. 2022

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