Portal de investigación
Janus Gold Nanostars-Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery
Autores de CIPF
Participantes ajenos a CIPF
- Hernández Montoto A
- Llopis-Lorente A
- Gorbe M
- M Terrés J
- Cao-Milán R
- Díaz de Greñu B
- Alfonso M
- Ibañez J
- Villalonga R
Grupos de Investigación
Abstract
Janus gold nanostar-mesoporous silica nanoparticle (AuNSt-MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-beta-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.
Datos de la publicación
- ISSN/ISSNe:
- 0947-6539, 1521-3765
- Tipo:
- Article
- Páginas:
- 8471-8478
- PubMed:
- 31012155
CHEMISTRY-A EUROPEAN JOURNAL WILEY-V C H VERLAG GMBH
Citas Recibidas en Web of Science: 37
Documentos
- No hay documentos
Filiaciones
Keywords
- drug delivery; gold; light-responsive nanodevices; mesoporous silica; NIR light
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