Portal de investigación
Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue
Fecha de publicación:
Fecha Ahead of Print:
Autores de CIPF
Participantes ajenos a CIPF
- Blandez, JF
- Alfonso, M
Grupos de Investigación
Abstract
In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 nm is highly quenched inside S3, yet a remarkable emission enhancement is observed upon cap hydrolysis in the presence of beta-galactosidase and dye release. The efficacy of the probe to detect cellular senescence is tested in vitro in melanoma SK-Mel-103 and breast cancer 4T1 cells and in vivo in palbociclib-treated BALB/cByJ mice bearing breast cancer tumor.
Datos de la publicación
- ISSN/ISSNe:
- 1433-7851, 1521-3773
- Tipo:
- Article
- Páginas:
- 15152-15156
- PubMed:
- 32416002
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION WILEY-V C H VERLAG GMBH
Citas Recibidas en Web of Science: 57
Documentos
- No hay documentos
Filiaciones
Keywords
- in vivo detection; mesoporous nanoparticles; Nile blue; NIR probes; senescence
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