Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat

Autores de CIPF

• Ana Agustí Feliu

  Autor

• Isabel Campillo Nuevo

  Autor

• Tiziano Balzano

  Autor

• Jerónimo Forteza Vila

  Autor

• 

  Vicente Felipo Orts

  Autor

Participantes ajenos a CIPF

• Benitez-Paez, A
• Lopez-Almela, I
• Romani-Perez, M
• Avena, NM
• Sanz, Y

Grupos de Investigación

• Laboratorio de Fisiopatología y Terapias de Enfermedades de la Visión.

  

  Jefe/a de Grupo

  Regina Rodrigo Nicolás

• Laboratorio de Neurobiología

  

  Jefe/a de Grupo

  Vicente Felipo Orts

Abstract

Food addiction (FA) is characterized by behavioral and neurochemical changes linked to loss of food intake control. Gut microbiota may influence appetite and food intake via endocrine and neural routes. The gut microbiota is known to impact homeostatic energy mechanisms, but its role in regulating the reward system is less certain. We show that the administration of Bacteroides uniformis CECT 7771 (B. uniformis) in a rat FA model impacts on the brain reward response, ameliorating binge eating and decreasing anxiety-like behavior. These effects are mediated, at least in part, by changes in the levels of dopamine, serotonin, and noradrenaline in the nucleus accumbens and in the expression of dopamine D1 and D2 receptors in the prefrontal cortex and intestine. B. uniformis reverses the fasting-induced microbiota changes and increases the abundance of species linked to healthy metabolotypes. Our data indicate that microbiota-based interventions might help to control compulsive overeating by modulating the reward response.

Keywords

• Bacteroides uniformis CECT 7771; Food addiction; Binge eating; Reward system; Dopamine; Microbiota; Gut-brain axis; Preclinical model