Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation.

Fecha de publicación: 21/08/2020

Autores de CIPF

Lorena Olivares González

Autor
Regina Rodrigo Nicolás

Autor

Participantes ajenos a CIPF

Sebastià N
Montoro A
Barquinero JF
Canyada-Martinez AJ
Hervás D
Gras P
Villaescusa JI
Martí-Bonmatí L
Muresan BT
Soriano JM
Campayo JM
Andani J
Alonso O

Grupos de Investigación

Laboratorio de Fisiopatología y Terapias de Enfermedades de la Visión.

Jefe/a de Grupo

Regina Rodrigo Nicolás

Abstract

The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year and cumulative), plasma antioxidant markers (total antioxidant capacity, extracellular superoxide dismutase activity, and glutathione/oxidized glutathione ratio), oxidative stress markers (nitrites and nitrates, and lipid peroxidation) and dietary intake (antioxidant capacity using ORAC values) were collected and analyzed from 28 non-exposed healthcare workers and 42 healthcare workers exposed to LDIR. Hospital staff exposed to LDIR presented a redox imbalance in blood that seems to correlate with dose. Workers from the Nuclear Medicine Unit were the most affected group with the lowest value of plasma antioxidant response and the highest value of plasma thiobarbituric acid reactive substances, TBARS (indicator of lipid peroxidation) of all four groups. Cumulative personal dose equivalent positively correlated with nitrites and negatively correlated with total antioxidant capacity in blood. The diet of healthcare workers from Nuclear Medicine Unit had higher ORAC values than the diet of non-exposed. Therefore, occupational exposure to LDIR, especially for the Nuclear Medicine Unit, seems to produce an imbalanced redox status in blood that would correlate with cumulative personal dose equivalent.

Datos de la publicación

ISSN/ISSNe:: 2076-3921, 2076-3921
Tipo:: Article
Páginas:: -
DOI:: 10.3390/antiox9090778
PubMed:: 32825731

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Métricas

Filiaciones

Sebastià N:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain

Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Olivares-González L:: Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain

Center for Biomedical Network Research on Rare Diseases (CIBERER), Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain
Montoro A:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain

Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Barquinero JF:: Biological Anthropology Unit Animal Biology, Plant Biology and Ecology Department, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain
Canyada-Martinez AJ:: Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Hervás D:: Biostatistics Unit, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Gras P:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Villaescusa JI:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain

Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Martí-Bonmatí L:: Biomedical Imaging Research Group GIBI230, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain

Service of Radiology, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Muresan BT:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Soriano JM:: Food & Health Lab, Institute of Materials Science, Parc Científic, Catedrático Agustín Escardino, Paterna (Valencia), University of Valencia, 46980 Valencia, Spain

Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain
Campayo JM:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Andani J:: Service of Occupational Risk Prevention, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Alonso O:: Service of Radiological Protection, Clinical Area of Medical Image, Avda. Fernando Abril Martorell, 106, Hospital U. P. La Fe, 46026 Valencia, Spain
Rodrigo R:: Pathophysiology and Therapies for Visual Disorders, Eduardo Primo Yúfera, 3, Research Center Príncipe Felipe (CIPF), 46012 Valencia, Spain

Center for Biomedical Network Research on Rare Diseases (CIBERER), Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain

Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia, Avda. Fernando Abril Martorell, 106, Health Research Institute Hospital La Fe (IISLaFe), 46026 Valencia, Spain

Joint Research Unit of Rare Diseases, CIPF-Health Research Institute La Fe, Eduardo Primo Yúfera, 3, 46012 Valencia, Spain

Keywords

antioxidant-oxidant status, ionizing radiation, occupational exposure, oxygen radical absorbance capacity (ORAC), personal dose equivalent

Proyectos asociados

Desarrollo de nanoterapias anti-inflamatorias en retinosis pigmentaria

Investigador Principal: REGINA RODRIGO NICOLÁS

INSTITUTO DE SALUD CARLOS III . 2019