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Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment

Fecha de publicación:

Autores de CIPF

Participantes ajenos a CIPF

  • Llopis-Lorente, A
  • de Luis, B
  • Jimenez-Falcao, S
  • Villalonga, R

Grupos de Investigación

Abstract

Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous silica (MS) nanoparticles functionalized with the enzyme glucose dehydrogenase (GDH) on the Au surface and with supramolecular nanovalves as caps on the MS surface, which is loaded with a cargo (dye or drug). The nanodevice acts as an AND logic gate and reads information from the solution (presence of glucose and nicotinamide adenine dinucleotide (NADI), which results in cargo release. We show the possibility of coimmobilizing GDH and the enzyme urease on nanoparticles to mimic an INHIBIT logic gate, in which the AND gate is switched off by the presence of urea. We also show that such nanodevices can deliver cytotoxic drugs in cancer cells by recognizing intracellular NAD(+) and the presence of glucose.

Datos de la publicación

ISSN/ISSNe:
1944-8244, 1944-8252

ACS Applied Materials & Interfaces  AMER CHEMICAL SOC

Tipo:
Article
Páginas:
26494-26500
PubMed:
30016064

Citas Recibidas en Web of Science: 21

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Keywords

  • biocomputing; nanorobots; logic gates; mesoporous nanoparticles; drug delivery

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