Toll-like receptors 2 and 4 differentially regulate the self-renewal and differentiation of spinal cord neural precursor cells.

Autores de CIPF

• Marina Sánchez Petidier

  Autor

• Consuelo Guerri Sirera

  Autor

• 

  M Victoria Moreno Manzano

  Autor

Grupos de Investigación

• Laboratorio de Regeneración Tisular y Neuronal

  

  Jefe/a de Grupo

  M Victoria Moreno Manzano

Abstract

Toll-like receptors (TLRs) represent critical effectors in the host defense response against various pathogens; however, their known function during development has also highlighted a potential role in cell fate determination and neural differentiation. While glial cells and neural precursor cells (NPCs) of the spinal cord express both TLR2 and TLR4, their influence on self-renewal and cell differentiation remains incompletely described.

Keywords

• Cell differentiation, Neural precursor cells, Neurogenesis, Self-renewal, Spinal cord, Toll-like receptors