Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.

Fecha de publicación: 18/04/2023

Autores de CIPF

Marta Rosa Hidalgo García

Autor
Deborah J Burks

Autor
María De La Iglesia Vayá

Autor
Amparo Galán Albiñana

Autor
Francisco García García

Autor

Participantes ajenos a CIPF

Guaita-Cespedes M
Grillo-Risco R
Fernández-Veledo S

Grupos de Investigación

Laboratorio de Neuroendocrinología Molecular

Jefe/a de Grupo

Deborah J Burks
Unidad de Bioinformática y Bioestadística

Jefe/a de Grupo

Francisco García García
Unidad Mixta CIPF-FISABIO de Imagen Biomédica

Abstract

As the housekeeping genes (HKG) generally involved in maintaining essential cell functions are typically assumed to exhibit constant expression levels across cell types, they are commonly employed as internal controls in gene expression studies. Nevertheless, HKG may vary gene expression profile according to different variables introducing systematic errors into experimental results. Sex bias can indeed affect expression display, however, up to date, sex has not been typically considered as a biological variable.

Datos de la publicación

ISSN/ISSNe:: 2042-6410, 2042-6410
Tipo:: Article
Páginas:: 20-20
DOI:: 10.1186/s13293-023-00506-x
PubMed:: 37072826

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Métricas

Filiaciones

Guaita-Cespedes M:: Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain

Hematology Research Group, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026, Valencia, Spain
Grillo-Risco R:: Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
Hidalgo MR:: Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
Fernández-Veledo S:: Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII, Institut d'Investigaciò Sanitària Pere Virgili (IISPV), Tarragona, Spain

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Burks DJ:: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain

Molecular Neuroendocrinology Laboratory, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
de la Iglesia-Vayá M:: Imaging Unit FISABIO-CIPF, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012, Valencia, Spain
Galán A:: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.

Molecular Neuroendocrinology Laboratory, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.
Garcia-Garcia F:: Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.