Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study.

Autores de CIPF

• José Francisco Catalá Senent

  Autor

• Francesc Ibáñez Cabanes

  Autor

• Consuelo Guerri Sirera

  Autor

• 

  Francisco García García

  Autor

• Maria Pascual Mora

  Autor

Participantes ajenos a CIPF

• Perpiñá-Clérigues C
• Mellado S
• Costa P
• Marcos M

Grupos de Investigación

• Unidad de Bioinformática y Bioestadística

  

  Jefe/a de Grupo

  Francisco García García

Abstract

Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation has been linked to several disorders, including metabolic syndrome, inflammation, and neurological dysfunction. Our recent results demonstrated the involvement of plasma EV microRNAs as possible amplifiers and biomarkers of neuroinflammation and brain damage induced by ethanol intoxication during adolescence. Considering the possible role of plasma EV lipids as regulatory molecules and biomarkers, we evaluated how acute ethanol intoxication differentially affected the lipid composition of plasma EVs in male and female adolescents and explored the participation of the immune response.

Keywords

• Adolescence, Alcohol, Extracellular vesicles, Functional profiling, Lipidomics, Sex-based differences