1. Inicio
  2. Publicaciones
  3. Sequential pore wall functionalization in covalent organic frameworks and application to stable camptothecin delivery systems

Sequential pore wall functionalization in covalent organic frameworks and application to stable camptothecin delivery systems

Fecha de publicación:

Autores de CIPF

Participantes ajenos a CIPF

  • Oliveira, AD
  • Rivero-Buceta, EM
  • Vidaurre-Agut, C
  • Misturini, A
  • Jorda, JL
  • Sastre, G
  • Pergher, SBC
  • Botella, P

Grupos de Investigación

Abstract

Post-synthetic modification of covalent organic frameworks (COFs) is strongly demanded in order to provide additional functionalities to their structures. However, the introduction of functional groups during the synthesis of two dimensional COFs (2D COFs) is highly discouraged, as they can interfere with the ox-ox stacking forces, compromising framework integrity. Here, we show that direct incorporation of nucleophyllic groups (e.g., primary amines) on pore wall during the synthesis of a 2D-COF (COF-5) is possible by sequential substitution of original monomers. Subsequent bonding of the antitumor drug camptothecin results in a stable hydrophobic drug delivery system. Water adsorption isotherms modelling indicates that the insertion of CPT ligand in the framework promotes a hydrophobic effect that protects a region of COF chain from boronate ester hydrolysis and resulting degradation, which is also proven by stability testing in physiological conditions. Furthermore, this hydrophobic nature favors cell internalization kinetics by promoting interactions with the lipophilic cell membrane. To the best of our knowledge, this is the first case of a stable drug delivery system based on covalently conjugated COFs.

Datos de la publicación

ISSN/ISSNe:
0928-4931, 1873-0191

Materials Science & Engineering C-Materials for Biological Applications  Elsevier BV

Tipo:
Article
Páginas:
-
PubMed:
32919629

Citas Recibidas en Web of Science: 18

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Covalent organic framework; Sequential functionalization; Framework stability; Water adsorption isotherms; Drug delivery systems; Camptothecin

Proyectos asociados

Transplant of combined cell therapy form clinical grade iPSC-derived cells with neuroprotective small chemicals in a SCI rat model for central regeneration of spinal pathways

Investigador Principal: M VICTORIA MORENO MANZANO

FUNDACION LA MARATO DE TV3 . 2018

Combinatory treatment of Neural precursor cells and a new nanoconjugate of Fasudil for the clinical application in Acute Spinal Cord Injury

Investigador Principal: MARIA JESUS VICENT DOCON

FUNDACION LA MARATO DE TV3 . 2018

Nuevo biomaterial bio-activo para la regeneración de lesiones medulares

Investigador Principal: M VICTORIA MORENO MANZANO

MINISTERIO DE ECON. Y COMPET. . 2019

Validación farmacológica in vivo de nanofármacos inhibidores de ROCK2 en cáncer de mama metastásico y lesión medular

Investigador Principal: M VICTORIA MORENO MANZANO

AGENCIA VALENCIANA DE INNOVACIÓN . 2019

Compartir