Combinatory treatment of Neural precursor cells and a new nanoconjugate of Fasudil for the clinical application in Acute Spinal Cord Injury

Datos básicos

Código Financiador:
Año inicial:
2018
Año final:
2021
PROY. INVEST. NACIONAL F.COMPETITIVA FIN. PRIVADA 100.000,00 €

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FUNDACION LA MARATO DE TV3

Resultados del Proyecto


A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells

Alvarez-Palomo, AB; (...); Edel, MJ

Article. 10.1002/stem.3358. 2021


A targeted polypeptide-based nanoconjugate as a nanotherapeutic for alcohol-induced neuroinflammation.

Cuesta, Carlos Manuel; (...); Guerri, Consuelo

Article. 10.1016/j.nano.2021.102376. 2021


Activation of Neurogenesis in Multipotent Stem Cells CulturedIn Vitroand in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3

Rodriguez-Jimenez, FJ; (...); Erceg, S

Article. 10.1007/s13311-020-00928-0. 2021


Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Cabrera-Garcia, A; (...); Botella, P

Article. 10.1016/j.jcis.2019.01.042. 2019


Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Arroyo-Crespo, JJ; (...); Vicent, MJ

Article. 10.1002/adfm.201800931. 2018

  • Open Access.

Author Correction: Mechanism and Consequences of The Impaired Hif-1a Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose.

García-Pastor C; (...); Lucio-Cazaña FJ

Correction. 10.1038/s41598-020-65511-1. 2020


Bioengineering Approaches for Bladder Regeneration

Serrano-Aroca, A, Vera-Donoso, CD, Moreno-Manzano, V

Review. 10.3390/ijms19061796. 2018


Biohybrids for spinal cord injury repair

Martínez-Ramos C; (...); Moreno-Manzano V

Article. 10.1002/term.2816. 2019


Combined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbits

Chicharro, D; (...); Sopena, J

Article. 10.1186/s12917-018-1577-y. 2018


Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression

Arroyo-Crespo JJ; (...); Vicent MJ

Article. 10.1002/ijc.32270. 2019


Design of personalised polymer based combination therapeutics for advanced stage breast cancer patients

Arminan, A; (...); Vicent, MJ

Meeting Abstract. 10.1158/1538-7445.AM2018-3726. 2018


Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

Cordoba-David, G; (...); Ramos, AM

Article. 10.1038/s41598-020-58974-9. 2020


Envisioning the future of polymer therapeutics for brain disorders

Rodriguez-Otormin, F; (...); Vicent, MJ

Review. 10.1002/wnan.1532. 2019


Ependymal cells in the spinal cord as neuronal progenitors

Moreno-Manzano, V

Article. 10.1016/j.coph.2019.11.008. 2020


EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P; (...); Gribbon, P

Article. 10.1177/2472555218816276. 2019


Exosomes in NSCLC as a source of biomarkers

Durendez, E; (...); Herrero, CJC

Meeting Abstract. 2019


Exosomes in NSCLC: Analysis of its cargo as a source of biomarkers

Durendez-Saez, E; (...); Camps, C

Meeting Abstract. 2019


FM19G11-Loaded Gold Nanoparticles Enhance the Proliferation and Self-Renewal of Ependymal Stem Progenitor Cells Derived from ALS Mice

Marcuzzo S; (...); Bernasconi P

Article. 10.3390/cells8030279. 2019


Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

Moura, LIF; (...); Florindo, HF

Review. 10.1039/c9mh00628a. 2019


Graphene oxide nanosheets versus carbon nanofibers: Enhancement of physical and biological properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) films for biomedical applications.

Rivera-Briso AL; (...); Serrano-Aroca Á

Article. 10.1016/j.ijbiomac.2019.10.034. 2020


High- throughput screening using a Drosophila model of Parkinson's disease

Lopez, FJ; (...); Paricio, N

Meeting Abstract. 2019


Higher-order interfiber interactions in the self-assembly of benzene-1,3,5-tricarboxamide-based peptides in water

Zagorodko, O; (...); Vicent, MJ

Article. 10.1039/d1py00304f. 2021

  • Open Access.

Human adipose-derived mesenchymal stem cells accelerate decellularized neobladder regeneration

Moreno-Manzano, V; (...); Vera-Donoso, CD

Article. 10.1093/rb/rbz049. 2020

  • Open Access.

Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Bonilla, P; (...); Moreno-Manzano, V

Article. 10.3390/ijms22115966. 2021


In Vivo Imaging of MMP-13 Activity Using a Specific Polymer-FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy

Duro-Castano, A; (...); Nagase, H

Article. 10.1002/adfm.201802738. 2018


Injectable Gel Form of a Decellularized Bladder Induces Adipose-Derived Stem Cell Differentiation into Smooth Muscle Cells In Vitro

Moreno-Manzano, V; (...); Serrano-Aroca, A

Article. 10.3390/ijms21228608. 2020


Isolation and phenotyping of potential stem cells from the umbilical cord of the bottlenose dolphin(Tursiops truncatus)

Mancia, A; (...); Moreno-Manzano, V

Article. 10.1387/ijdb.190042am. 2019


Lipid-Polyglutamate Nanoparticle Vaccine Platform

Van Lysebetten, D; (...); De Geest, BG

Article. 10.1021/acsami.0c20607. 2021

  • Open Access.

Mechanism and Consequences of The Impaired Hif-1 alpha Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose

Garcia-Pastor, C; (...); Lucio-Cazana, FJ

Article. 10.1038/s41598-019-52310-6. 2019


Metabolomics facilitates the discrimination of the specific and-cancer effects of free and polymer conjugated doxorubicin in breast cancer models

Arminan, A; (...); Pineda-Lucena, A

Article. 10.1016/j.biomaterials.2018.02.015. 2018


Molecular platforms for targeted drug delivery

Maso K; (...); Pasut G

Review. 10.1016/bs.ircmb.2019.03.001. 2019


Nanomedicine for the Treatment of Advanced Prostate Cancer

Vicente-Ruiz, S; (...); Vicent, MJ

Review. 10.1002/adtp.202000136. 2021


Near-Infrared Activatable Phthalocyanine Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy

Cheah, HY; (...); Kiew, LV

Article. 10.1021/acs.molpharmaceut.8b00132. 2018


Optogenetic Modulation of Neural Progenitor Cells Improves Neuroregenerative Potential

Giraldo, E; (...); Moreno-Manzano, V

Article. 10.3390/ijms22010365. 2021


Organized Neurogenic-Niche-Like Pinwheel Structures Discovered in Spinal Cord Tissue-Derived Neurospheres

Rodriguez-Jimenez FJ; (...); Erceg S

Article. 10.3389/fcell.2019.00334. 2019


Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer

Plyduang, T; (...); Vicent, MJ

Article. 10.1002/marc.201800265. 2018


Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1016/j.jconrel.2021.02.005. 2021


Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury

Tejedor, S; (...); Vicent, MJ

Article. 10.1002/adhm.202002121. 2021


Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders.

Conejos-Sánchez I; (...); Vicent MJ

Article. 10.1039/c9nr06187h. 2020

  • Open Access.

Polypeptide-based conjugates as versatile therapeutics as single agents or in combination therapy

Zagorodko, O; (...); Vicent, M

Meeting Abstract. 2019


Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

Dolz-Pérez I; (...); Vicent MJ

Article. 10.1016/j.jconrel.2019.12.016. 2020


PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells

Rivero-Buceta, E; (...); Botella, P

Article. 10.1021/acsomega.8b02909. 2019


Regulation of P2X7 receptor by Sp1 nuclear factor: role in neuroregeneration

Gomez-Villafuertes, R; (...); Miras-Portugal, MT

Meeting Abstract. 2018


Sequential pore wall functionalization in covalent organic frameworks and application to stable camptothecin delivery systems

Oliveira, AD; (...); Botella, P

Article. 10.1016/j.msec.2020.111263. 2020


SQANTI: extensive characterization of long-read transcript sequences for quality control in full-length transcriptome identification and quantification (vol 28, pg 396, 2018)

Tardaguila M; (...); Conesa A

Correction. 10.1101/gr.239137.118. 2018


Study of Exosomes in NSCLC for Biomarkers Searching

Durendez-Saez, E; (...); Camps, C

Meeting Abstract. 10.1016/j.jtho.2019.08.526. 2019


tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing

de la Fuente, L; (...); Conesa, A

Article. 10.1186/s13059-020-02028-w. 2020

  • Open Access.

Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates

Duro-Castano, A; (...); Vicent, MJ

Article. 10.1126/sciadv.abf9180. 2021

  • Open Access.

Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide

Lepland, A; (...); Scodeller, P

Article. 10.1021/acs.molpharmaceut.0c00226. 2020


The generation of stabilized supramolecular nanorods from star-shaped polyglutamates

Zagorodko, O, Nebot, VJ, Vicent, MJ

Article. 10.1039/c9py01442j. 2020

  • Open Access.

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation.

Melnyk T; (...); Vicent MJ

Article. 10.1016/j.addr.2020.10.007. 2020


Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Arroyo-Crespo JJ; (...); Vicent MJ

Article. 10.1016/j.biomaterials.2018.09.023. 2018


Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen

Marti-Centelles, R; (...); Escuder, B

Article. 10.1021/acsabm.0c01422. 2021


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